A New Horizon in Biocompatible Membrane: The Role of Collagen and Silk Fibroin in Tissue Regeneration-Case series

Jyoti T Naik, Rudrakshi C* and M L V Prabhuji

Background: Silk extracted from the silkworm is prized for its exceptional biological and mechanical qualities for its versatility in multiple fields as a biomaterial, most prominently showcased in bone tissue engineering scaffolding. In recent times, silk protein-derived biomaterials have been utilized as scaffolds for guiding bone regeneration. Bovine collagen is selected to enhance the biological function of silk fibroin, as a composite membrane. Thus, considering all these characteristics, we have fabricated silk fibroin into a collagen membrane for evaluation. Therefore, we have a cross-linked collagen membrane with silk fibroin for soft tissue augmentation. 

Materials and methods: We have fabricated a silk fibroin-collagen membrane, a composite membrane using lyphophilization to form a fibroin/collagen scaffold for the evaluation of gingival tissue thickness. A total of 10 patients with Stage II/III, Grade B periodontitis received this composite membrane. Patients were re-evaluated at 6 and 12 weeks for clinical parameters of soft tissue gingival thickness, keratinized tissue width, and wound healing. Values obtained were statistically analyzed with p - value ≤ 0.05. 

Results: The addition of silk fibroin to collagen membrane for augmentation of ridge defects, infrabony defects, socket augmentation, and in immediate implant placement for soft tissue augmentation resulted in statistically significant improvement of clinical parameters.

Conclusion: Soft tissue augmentation using a composite membrane with silk fibroin demonstrated marginal but statistically significant changes in gingival phenotype. In various oral soft tissue defects. This composite membrane shows a promising alternative to connective tissue graft.

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Published on: Nov 28, 2024 Pages: 18-24

Full Text PDF Full Text HTML DOI: 10.17352/jbm.000043
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