Interpretation of Deletion of Y-allele in Some Cases

Anuj Kumari*, Naresh Kumar, Seerat, Poonam Sharma and Anil Aggrawal

DNA profiling plays a crucial role in sexual assault cases, murder and other missing identity cases because individuals can be identified through DNA profiling in unidentified dead body or mass disaster cases. It was observed that a DNA profile shows a Y deletion on amelogenin in some cases due to a mutation in the gene. A male DNA sample may sometimes be incorrectly represented as female if there is a deletion in a specific region of y-chromosome regions it expresses no alleles on some of the markers of Y STR. Sometimes it shows no peaks, double peaks or 4 peaks in Y STR markers. DNA quantification using specialised quantification kits like Quantifiler Trio can play an important role in sex determination, as this kit assesses both total human DNA and male-specific DNA targets. This issue can be addressed by forensic scientists through the use of multiple Y-chromosome markers (more than three) and determination due to Y-chromosome deletions. Further, there are deletion have been observed on # markers of Y-STR kits.

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Published on: Jul 17, 2026 Pages: 4-6

Full Text PDF Full Text HTML DOI: 10.17352/fst.000028
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