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Annals of Systems Biology

    Abstract

    Open Access Opinion Article ID: ASB-7-123

    A Rapid Fluorescent in vitro Assay Suitable for Studying the Kinetics of O6-Alkylguanine Lesion Progression to DNA Inter-Strand Cross-Links and the Kinetics of the Primary Lesion’s Repair

    Philip G Penketh*

    An assay is described that permits the study of the kinetics of DNA cross-link precursor formation, the kinetics of cross-formation, and the kinetics of the repair of these DNA cross-link precursor lesions, at physiological pH values. Due to the relatively rapid nature of these processes existing assays are not suited to the study of these processes. Data obtained using this assay can be used to optimize the design of certain classes of anticancer drugs.

    Keywords:

    Published on: Nov 15, 2024 Pages: 51-53

    Full Text PDF Full Text HTML DOI: 10.17352/asb.000023
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    Editor-in-Chief

    Hermis Iatrou
    University of Athens, Greece
    Open Journal of Chemistry
    Arghya Narayan Banerjee
    Yeungnam University, South Korea
    International Journal of Nanomaterials, Nanotechnology and Nanomedicine
    Ennio Duranti
    University of Siena, Italy
    Archives of Renal Diseases and Management
    Dong Zhao
    China University of Political Science and Law, China
    Forensic Science Today
    Hamza Mujagic
    Former member of MGH, USA
    International Journal of Immunotherapy and Cancer Research
    Nikolaos Papanas
    Democritus University of Thrace , Greece
    International Journal of Vascular Surgery and Medicine
    Jose Manuel Ramia-Angel
    Guadalajara University Hospital , Spain
    Journal of Surgery and Surgical Research
    Stavros Dimopoulos
    University of Athens, Greece
    Journal of Novel Physiotherapy and Physical Rehabilitation
    Lianbo Yu
    Ohio State University, USA
    Open Journal of Bioinformatics and Biostatistics
    Kwang-Hyun Baek
    Yeungnam University, Korea
    International Journal of Immunotherapy and Cancer Research

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