A sirtuin 6 activator in the pipeline: New perspectives in depressive disorder treatment

Ana Carolina de Oliveira Pereira, Gabriel Almeida Mendonça da Silva, José C. Barros and Raoni Schroeder Borges Gonçalves*

Major Depressive Disorder (MDD) is among the most prevalent mental illnesses worldwide. Its symptoms include persistent feelings of sadness, loss of interest in previously enjoyed activities, and a lack of motivation for daily tasks. While FDA-approved medications are available, they often come with side effects, especially those targeting monoamine neurotransmitters like SSRIs and SNRIs. Thus, there is a need for innovative medications with different mechanisms of action. Sp-624, a derivative of griseofulvin, is currently undergoing clinical trials for MDD treatment. It acts as a sirtuin 6 (SIRT6) activator, offering a novel approach to treating this disorder. This article discusses the biochemical aspects related to the mechanism of action of sp-624, provides a brief overview of related patents, and highlights ongoing clinical trials involving this substance. 

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Published on: Apr 30, 2024 Pages: 1-4

Full Text PDF Full Text HTML DOI: 10.17352/ojpg.000013
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